The aircraft was heading to the municipality of Redencao in the northern state of Para, with a pilot and a couple aboard, when it went down on a farm shortly after takeoff, Xinhua reported.
Firefighters, emergency medical teams and police responded to the crash and confirmed the deaths.
The two victims were identified as Doctor Ederson da Silva and his wife, Roseli Amarilda Pechulo Silva. The pilot was taken to a hospital in the region.
The cause of the crash is under investigation.
MNA